Cart
sales@molnova.com
Monastrol (b)
CAS No. 329689-23-8
Monastrol (b)( ±)-Monastrol )
Catalog No. M14088 CAS No. 329689-23-8
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 84 | In Stock |
|
| 25MG | 171 | In Stock |
|
| 50MG | 288 | In Stock |
|
| 100MG | 514 | In Stock |
|
| 500MG | 1125 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMonastrol (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
-
DescriptionA potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition); does not inhibit microtubule motility driven by conventional kinesin at 200 uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S)-monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.
-
In Vitro——
-
In Vivo——
-
Synonyms±)-Monastrol
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetKinesin
-
RecptorEg5
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number329689-23-8
-
Formula Weight292.35344
-
Molecular FormulaC14H16N2O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 33 mg/mL
-
SMILESCCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
-
Chemical Name5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Mayer TU, et al. Science. 1999 Oct 29;286(5441):971-4.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4;150(5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21;42(2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep;9(9):989-96.
molnova catalog
related products
-
BRD 9876
BRD 9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM.
-
MK-8267
MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
-
GSK-923295
The first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM.
